![]() ![]() Mammalian protein RAP46: An interaction partner and modulation of 70 kDa heat shock proteins. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. Takayama S, Bimston DN, Matsuzawa S et al. GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. ![]() Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity. Guidebook to Molecular Chaperones and Protein Folding Catalysts. Post-translational protein import and folding. Escherichia coli Dnaj and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK. Initiation of lambda DNA replication with purified host-and bacteriophage-encoded proteins: The role of the dnaK, dnaJ and grpE heat shock proteins. Ordered assembly of nucleoprotein structures at the bacteriophage lambda replication origin during the initiation of DNA replication. Initiation of the DNA replication of bacteriophage lambda in Escherichia coli K12. Genetic analysis of two genes, dnaj and dnaK, necessary for Escherichia coli and bacteriophage lambda DNA replication. The J-protein family: Modulating protein assembly, disassembly and translocation. Structure, function and evolution of DnaJ: Conservation and adaptation of chaperone function. The J-domain family and the recruitment of chaperone power. The role of ATP in the functional cycle of the DnaK chaperone system. McCarty JS, Buchberger A, Reinstein J et al. Complex formation between clathrin and uncoating AT-Pase. Complex stability and conformation of bound substrate protein. Structural analysis of substrate binding by the molecular chaperone DnaK. The archaeal molecular chaperone machine: Peculiarities and paradoxes. Hsp70 chaperones: Cellular functions and molecular mechanism. Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells. This process is experimental and the keywords may be updated as the learning algorithm improves. These keywords were added by machine and not by the authors. Cystic Fibrosis Transmembrane Conductance Regulator.Like their Hsp70 partners, the eukaryotic NEFs also play diverse roles in cellular processes, and recent structural studies have elucidated their mechanism of action. Although a NEF for a prokaryotic Hsp70, DnaK has been known and studied for some time, eukaryotic Hsp70s NEFs were discovered more recently. The ability of Hsp70 to perform these diverse functions is regulated by two other classes of proteins: Hsp40s (also known as J-domain-containing proteins) and Hsp70-specific nucleotide exchange factors (NEFs). As a result, Hsp70s can enhance protein folding and degradation, the assembly of multi-protein complexes, and the catalytic activity of select enzymes. Hsp70 molecular chaperones hydrolyze and re-bind ATP concomitant with the binding and release of aggregation-prone protein substrates. ![]()
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